The aim of present study was to develop colon targeted system for prednisolone using guar gum and tamarind seed polysaccharide. Matrix formulations containing various proportions of guar gum and tamarind seed polysaccharide were prepared by wet granulation technique. Later on tablets were prepared by using various concentrations of guar gum and tamarind seed polysaccharide as release controlling layers on either side of matrix tablets of prednisolone. All the formulations were evaluated for in-process quality control tests. The interaction between the excipients and prednisolone was also studied through FTIR spectroscopy. Tablets were then prepared by wet granulation method with different ratio of polysaccharides and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. In-vitro drug release studies were performed in conditions simulating stomach to colon transit The in-vitro drug release study was undertaken at 37±0.5°C in 0.1N HCl for 2 h; followed by pH 7.4 phosphate buffer (3h) finally in simulated colonic fluid pH 6.8 phosphate buffer containing 4% w/v rat ceacal content for 15 h. Results indicated that guar gum was alone failed to control drug release. When studies were continued in colonic fluids, matrix tablets released almost 100% drug. whereas, prednisolone formulations did not release drug in stomach and small intestine, but delivered drug to the colon resulting in slow absorption of the drug and making drug available for local action in the colon.
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